Ontology highlight
ABSTRACT:
SUBMITTER: Ohtani H
PROVIDER: S-EPMC3744724 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Genes & development 20130801 15
The Piwi-piRNA (PIWI-interacting RNA) complex (Piwi-piRISC) in Drosophila ovarian somatic cells represses transposons transcriptionally to maintain genome integrity; however, the underlying mechanisms remain obscure. Here, we reveal that DmGTSF1, a Drosophila homolog of gametocyte-specific factor 1 (GTSF1) (which is required for transposon silencing in mouse testes), is necessary for Piwi-piRISC to repress target transposons and neighboring genes. DmGTSF1 depletion affected neither piRNA biogene ...[more]