Unknown

Dataset Information

0

Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids.

ABSTRACT: Novel bioactive lipids were identified from a Guamanian cyanobacterium, the Pseudomonas aeruginosa quorum sensing inhibitor pitinoic acid A (1) and the anti-inflammatory pitinoic acids B (2) and C. The structure of 2 was confirmed by synthesis, which also allowed for biological evaluation. Since 2 is an ester of pitinoic acids A and C, it represents a prodrug strategy to liberate dual biological activity for the management of P. aeruginosa infections and their associated inflammation.

SUBMITTER: Montaser R 

PROVIDER: S-EPMC3785295 | biostudies-other | 2013 Aug

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids.

Montaser Rana R   Paul Valerie J VJ   Luesch Hendrik H  

Organic letters 20130805 16

Novel bioactive lipids were identified from a Guamanian cyanobacterium, the Pseudomonas aeruginosa quorum sensing inhibitor pitinoic acid A (1) and the anti-inflammatory pitinoic acids B (2) and C. The structure of 2 was confirmed by synthesis, which also allowed for biological evaluation. Since 2 is an ester of pitinoic acids A and C, it represents a prodrug strategy to liberate dual biological activity for the management of P. aeruginosa infections and their associated inflammation. ...[more]