Ontology highlight
ABSTRACT:
SUBMITTER: Sadhukhan T
PROVIDER: S-EPMC3826742 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Disease markers 20120101 6
Leucine rich repeat kinase 2 (LRRK2) gene defects cause Parkinson's disease (PD). Recently, LRRK2 has also been shown by genome wide association (GWA) studies to be a susceptibility gene for the disease. In India mutations in LRRK2 is a rare cause of PD. We, therefore, genotyped 64 SNPs across LRRK2 in 161 control samples and finally studied 6 haplotype tagging SNPs for association-based study on 300 cases and 446 ethnically matched controls to explore the potential role of LRRK2 as a susceptibi ...[more]