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Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.

ABSTRACT: Developmentally regulated genes in Drosophila, which are conserved through evolution, are potential candidates for key functions in biological processes such as cell cycle, programmed cell death, and cancer. We report cloning and characterization of the human homologue of the Drosophila seven in absentia gene (HUMSIAH), which codes for a 282 amino acids putative zinc finger protein. HUMSIAH is localized on human chromosome 16q12-q13. This gene is activated during the physiological program of cell death in the intestinal epithelium. Moreover, human cancer-derived cells selected for suppression of their tumorigenic phenotype exhibit constitutively elevated levels of HUMSIAH mRNA. A similar pattern of expression is also displayed by the p21waf1. These results suggest that mammalian seven in absentia gene, which is a target for activation by p53, may play a role in apoptosis and tumor suppression.

SUBMITTER: Nemani M 

PROVIDER: S-EPMC38591 | biostudies-other | 1996 Aug

REPOSITORIES: biostudies-other

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Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.

Nemani M M   Linares-Cruz G G   Bruzzoni-Giovanelli H H   Roperch J P JP   Tuynder M M   Bougueleret L L   Cherif D D   Medhioub M M   Pasturaud P P   Alvaro V V   der Sarkissan H H   Cazes L L   Le Paslier D D   Le Gall I I   Israeli D D   Dausset J J   Sigaux F F   Chumakov I I   Oren M M   Calvo F F   Amson R B RB   Cohen D D   Telerman A A  

Proceedings of the National Academy of Sciences of the United States of America 19960801 17

Developmentally regulated genes in Drosophila, which are conserved through evolution, are potential candidates for key functions in biological processes such as cell cycle, programmed cell death, and cancer. We report cloning and characterization of the human homologue of the Drosophila seven in absentia gene (HUMSIAH), which codes for a 282 amino acids putative zinc finger protein. HUMSIAH is localized on human chromosome 16q12-q13. This gene is activated during the physiological program of cel  ...[more]