Ontology highlight
ABSTRACT:
SUBMITTER: Calcul L
PROVIDER: S-EPMC3877901 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Marine drugs 20131212 12
We conducted a screening campaign to investigate fungi as a source for new antimalarial compounds. A subset of our fungal collection comprising Chinese mangrove endophytes provided over 5000 lipophilic extracts. We developed an accelerated discovery program based on small-scale cultivation for crude extract screening and a high-throughput malaria assay. Criteria for hits were developed and high priority hits were subjected to scale-up cultivation. Extracts from large scale cultivation were fract ...[more]