Ontology highlight
ABSTRACT:
SUBMITTER: Zigman M
PROVIDER: S-EPMC3899817 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Development (Cambridge, England) 20140201 3
Hox genes are classically ascribed to function in patterning the anterior-posterior axis of bilaterian animals; however, their role in directing molecular mechanisms underlying morphogenesis at the cellular level remains largely unstudied. We unveil a non-classical role for the zebrafish hoxb1b gene, which shares ancestral functions with mammalian Hoxa1, in controlling progenitor cell shape and oriented cell division during zebrafish anterior hindbrain neural tube morphogenesis. This is likely d ...[more]