Ontology highlight
ABSTRACT:
SUBMITTER: Keeton EK
PROVIDER: S-EPMC3916880 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Keeton Erika K EK McEachern Kristen K Dillman Keith S KS Palakurthi Sangeetha S Cao Yichen Y Grondine Michael R MR Kaur Surinder S Wang Suping S Chen Yuching Y Wu Allan A Shen Minhui M Gibbons Francis D FD Lamb Michelle L ML Zheng Xiaolan X Stone Richard M RM Deangelo Daniel J DJ Platanias Leonidas C LC Dakin Les A LA Chen Huawei H Lyne Paul D PD Huszar Dennis D
Blood 20131220 6
Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. AZD1208 is a potent, highly selective, and orally available Pim kinase inhibitor that effectively inhibits all three isoforms at <5 nM or <150 nM in enzyme and cell assays, respectively. AZD1208 inhibited the growth of 5 of 14 acute myeloid leukemia (AML) cell lines tested, and sensitivity corre ...[more]