Ontology highlight
ABSTRACT:
SUBMITTER: Petridis C
PROVIDER: S-EPMC3929874 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
British journal of cancer 20131224 4
<h4>Background</h4>Invasive lobular breast cancer (ILC) and lobular carcinoma in situ (LCIS) are characterised by loss of E-cadherin expression. However germline CDH1 mutations are rare in cases of ILC with no family history of hereditary diffuse gastric cancer (HDGC) and have not been described in women with LCIS.<h4>Methods</h4>We screened the CDH1 gene in 50 cases of bilateral LCIS/ILC using Sanger sequencing and MLPA.<h4>Results</h4>Sanger sequencing revealed four pathogenic germline mutatio ...[more]