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Targeting metabolic scavenging in pancreatic cancer.

ABSTRACT: Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth.

SUBMITTER: Lyssiotis CA 

PROVIDER: S-EPMC3930347 | biostudies-other | 2014 Jan

REPOSITORIES: biostudies-other

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Targeting metabolic scavenging in pancreatic cancer.

Lyssiotis Costas A CA   Cantley Lewis C LC  

Clinical cancer research : an official journal of the American Association for Cancer Research 20131028 1

Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth. ...[more]