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Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

ABSTRACT: We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.

SUBMITTER: Olofsson B 

PROVIDER: S-EPMC39839 | biostudies-other | 1996 Mar

REPOSITORIES: biostudies-other

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Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

Olofsson B B   Pajusola K K   Kaipainen A A   von Euler G G   Joukov V V   Saksela O O   Orpana A A   Pettersson R F RF   Alitalo K K   Eriksson U U  

Proceedings of the National Academy of Sciences of the United States of America 19960301 6

We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 2  ...[more]

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