Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto S
PROVIDER: S-EPMC4000088 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Matsumoto Shinji S Fujii Shinsuke S Sato Akira A Ibuka Souji S Kagawa Yoshinori Y Ishii Masaru M Kikuchi Akira A
The EMBO journal 20140220 7
Growth factor-dependent epithelial morphological changes and proliferation are essential for the formation of tubular structures, but the underlying molecular mechanisms are poorly understood. Co-stimulation with Wnt3a and epidermal growth factor (Wnt3a/EGF) induced development of tubes consisting of intestinal epithelial cells by inducing expression of Arl4c, an Arf-like small GTP-binding protein, in three-dimensional culture, while stimulation with Wnt3a or EGF alone did not. Arl4c expression ...[more]