Unknown

Dataset Information

0

4-1BB signaling beyond T cells.


ABSTRACT: Originally discovered as a T cell-activating molecule, 4-1BB (CD137) is now also recognized as an activator of non-T cells, thus imparting a new dimension to its potential in vivo effects. 4-1BB expression is seen on a variety of non-T cells including activated dendritic cells (DCs), monocytes, neutrophils, B cells and natural killer (NK) cells, and promotes their individual effector functions. The T cell- and non-T cell-activating ability of 4-1BB may be the basis of its powerful anti-cancer, anti-autoimmune and anti-viral effects. Here we discuss the consequence and importance of 4-1BB signaling in non-T cells. We consider its effects on immune regulation, and the distinct and/or overlapping pathways involved in these responses, as well as possible therapeutic applications.

SUBMITTER: Vinay DS 

PROVIDER: S-EPMC4002439 | biostudies-other | 2011 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4593955 | biostudies-literature
| S-EPMC7279007 | biostudies-literature
| S-EPMC4594309 | biostudies-other
| S-EPMC2636986 | biostudies-literature
| S-EPMC8222499 | biostudies-literature
| S-EPMC7554708 | biostudies-literature
| S-EPMC3368625 | biostudies-other
| S-EPMC8563288 | biostudies-literature
| S-EPMC3115238 | biostudies-literature
| S-EPMC5295778 | biostudies-literature