Dataset Information
Degradation of specific nuclear proteins occurs in the cytoplasm in Saccharomyces cerevisiae.
Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4012479 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Publications
Degradation of specific nuclear proteins occurs in the cytoplasm in Saccharomyces cerevisiae.
Genetics 20140312 1
The ubiquitin/proteasome system has been characterized extensively, although the site of nuclear substrate turnover has not been established definitively. We report here that two well-characterized nuclear proteins are stabilized in nuclear export mutants in Saccharomyces cerevisiae. The requirement for nuclear export defines a new regulatory step in intracellular proteolysis. ...[more]