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Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

ABSTRACT: Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.

SUBMITTER: Stuhmer W 

PROVIDER: S-EPMC401447 | biostudies-other | 1989 Nov

REPOSITORIES: biostudies-other

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Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

Stühmer W W   Ruppersberg J P JP   Schröter K H KH   Sakmann B B   Stocker M M   Giese K P KP   Perschke A A   Baumann A A   Pongs O O  

The EMBO journal 19891101 11

Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversi  ...[more]