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Principles of protein-protein interactions.

ABSTRACT: This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.

SUBMITTER: Jones S 

PROVIDER: S-EPMC40170 | biostudies-other | 1996 Jan

REPOSITORIES: biostudies-other

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Principles of protein-protein interactions.

Jones S S   Thornton J M JM  

Proceedings of the National Academy of Sciences of the United States of America 19960101 1

This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that r  ...[more]