Ontology highlight
ABSTRACT:
SUBMITTER: Step SE
PROVIDER: S-EPMC4018489 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Genes & development 20140501 9
Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ), the adipocyte-predominant nuclear receptor (NR). The classic model, involving binding of ligand to the NR on DNA, explains positive regulation of gene expression, but ligand-dependent repression is not well understood. We addressed this issue by studying the direct effects of ro ...[more]