Ontology highlight
ABSTRACT:
SUBMITTER: Tang H
PROVIDER: S-EPMC4025819 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20120328 5
The renal outer medullary potassium channel (ROMK or Kir1.1) is a putative drug target for a novel class of diuretics that could be used for the treatment of hypertension and edematous states such as heart failure. An internal high-throughput screening campaign identified 1,4-bis(4-nitrophenethyl)piperazine (5) as a potent ROMK inhibitor. It is worth noting that this compound was identified as a minor impurity in a screening hit that was responsible for all of the initially observed ROMK activit ...[more]