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Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers.

ABSTRACT: A constitutional isomeric library synthesized by a modular approach has been used to discover six amphiphilic Janus dendrimer primary structures, which self-assemble into uniform onion-like vesicles with predictable dimensions and number of internal bilayers. These vesicles, denoted onion-like dendrimersomes, are assembled by simple injection of a solution of Janus dendrimer in a water-miscible solvent into water or buffer. These dendrimersomes provide mimics of double-bilayer and multibilayer biological membranes with dimensions and number of bilayers predicted by the Janus compound concentration in water. The simple injection method of preparation is accessible without any special equipment, generating uniform vesicles, and thus provides a promising tool for fundamental studies as well as technological applications in nanomedicine and other fields.

SUBMITTER: Zhang S 

PROVIDER: S-EPMC4078827 | biostudies-other | 2014 Jun

REPOSITORIES: biostudies-other

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Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers.

Zhang Shaodong S   Sun Hao-Jan HJ   Hughes Andrew D AD   Moussodia Ralph-Olivier RO   Bertin Annabelle A   Chen Yingchao Y   Pochan Darrin J DJ   Heiney Paul A PA   Klein Michael L ML   Percec Virgil V  

Proceedings of the National Academy of Sciences of the United States of America 20140609 25

A constitutional isomeric library synthesized by a modular approach has been used to discover six amphiphilic Janus dendrimer primary structures, which self-assemble into uniform onion-like vesicles with predictable dimensions and number of internal bilayers. These vesicles, denoted onion-like dendrimersomes, are assembled by simple injection of a solution of Janus dendrimer in a water-miscible solvent into water or buffer. These dendrimersomes provide mimics of double-bilayer and multibilayer b  ...[more]