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Synthesis of ?-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines.

ABSTRACT: A facile and efficient synthetic protocol for the synthesis of ?-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields.

SUBMITTER: Adiyala PR 

PROVIDER: S-EPMC4168875 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines.

Adiyala Praveen Reddy PR   Chandrasekhar D D   Kapure Jeevak Sopanrao JS   Reddy Chada Narsimha CN   Maurya Ram Awatar RA  

Beilstein journal of organic chemistry 20140902

A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields. ...[more]