Ontology highlight
ABSTRACT:
SUBMITTER: Alba-Castellon L
PROVIDER: S-EPMC4198692 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Neoplasia (New York, N.Y.) 20140501 5
Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of mesenchymal stem cells (MSCs), preventing their premature differentiation. Now, we show that Snail1 controls the tumorigenic properties of mesenchymal cells. Increased Snail1 expression provides tumorigenic capabilities to fibroblastic cells; on the contrary, Snail1 depletion de ...[more]