Alterations in the nuclear proteome of HIV-1 infected T-cells.
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ABSTRACT:
SUBMITTER: DeBoer J
PROVIDER: S-EPMC4253593 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Publications
Alterations in the nuclear proteome of HIV-1 infected T-cells.
DeBoer Jason J Jagadish Teena T Haverland Nicole A NA Madson Christian J CJ Ciborowski Pawel P Belshan Michael M
Virology 20140919
Virus infection of a cell involves the appropriation of host factors and the innate defensive response of the cell. The identification of proteins critical for virus replication may lead to the development of novel, cell-based inhibitors. In this study we mapped the changes in T-cell nuclei during human immunodeficiency virus type 1 (HIV-1) at 20 hpi. Using a stringent data threshold, a total of 13 and 38 unique proteins were identified in infected and uninfected cells, respectively, across all ...[more]
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