Ontology highlight
ABSTRACT:
SUBMITTER: Grimmer MR
PROVIDER: S-EPMC4259145 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Grimmer Matthew R MR Farnham Peggy J PJ
Epigenomics 20140101 5
Transcriptional misregulation is involved in the development of many diseases, especially neoplastic transformation. Distal regulatory elements, such as enhancers, play a major role in specifying cell-specific transcription patterns in both normal and diseased tissues, suggesting that enhancers may be prime targets for therapeutic intervention. By focusing on modulating gene regulation mediated by cell type-specific enhancers, there is hope that normal epigenetic patterning in an affected tissue ...[more]