STAT1-S727 - the license to kill.

ABSTRACT: Serine phosphorylation has generally been considered indispensable for full transcriptional activity of STAT proteins. Recent data indicate that CDK8-mediated phosphorylation of signal transducer and activator of transcription 1 (STAT1) on S727 inhibits natural killer (NK) cell cytotoxicity and restrains tumor surveillance. These findings implicate CDK8 as a promising target for immunotherapy.

SUBMITTER: Putz EM 

PROVIDER: S-EPMC4292214 | biostudies-other | 2014 Oct

REPOSITORIES: biostudies-other