Tumor-associated antigen specific CD8(+) T cells in hepatocellular carcinoma - a promising target for immunotherapy.

ABSTRACT: Immunotherapy is a promising treatment option for patients with hepatocellular carcinoma (HCC). Indeed, CD8(+) T-cell responses against various tumor antigens occur in these patients. However, these antitumoral T cells show a severely impaired effector function. Several immunosuppressive mechanisms contribute to this T-cell failure, including regulatory T cells and inhibitory receptors.

SUBMITTER: Schmidt N 

PROVIDER: S-EPMC4292268 | biostudies-other | 2014 Oct

REPOSITORIES: biostudies-other