Ontology highlight
ABSTRACT:
SUBMITTER: Caiazzo M
PROVIDER: S-EPMC4297873 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Caiazzo Massimiliano M Giannelli Serena S Valente Pierluigi P Lignani Gabriele G Carissimo Annamaria A Sessa Alessandro A Colasante Gaia G Bartolomeo Rosa R Massimino Luca L Ferroni Stefano S Settembre Carmine C Benfenati Fabio F Broccoli Vania V
Stem cell reports 20141231 1
Direct cell reprogramming enables direct conversion of fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors. This approach is rapid and simple, generating the cell types of interest in one step. However, it remains unknown whether this technology can be applied to convert fibroblasts into astrocytes, the third neural lineage. Astrocytes play crucial roles in neuronal homeostasis, and their dysfunctions contribute to the origi ...[more]