Ontology highlight
ABSTRACT:
SUBMITTER: Kao DI
PROVIDER: S-EPMC4325230 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Stem cell reports 20150115 2
Although endothelial cells have been shown to affect mouse pancreatic development, their precise function in human development remains unclear. Using a coculture system containing human embryonic stem cell (hESC)-derived progenitors and endothelial cells, we found that endothelial cells play a stage-dependent role in pancreatic development, in which they maintain pancreatic progenitor (PP) self-renewal and impair further differentiation into hormone-expressing cells. The mechanistic studies sugg ...[more]