Ontology highlight
ABSTRACT:
SUBMITTER: Barrenas F
PROVIDER: S-EPMC4340895 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Clinical and vaccine immunology : CVI 20150114 3
Vesicular stomatitis virus expressing Zaire Ebola virus (EBOV) glycoprotein (VSVΔG/EBOVgp) could be used as a vaccine to meet the 2014 Ebola virus outbreak. To characterize the host response to this vaccine, we used mRNA sequencing to analyze peripheral blood mononuclear cells (PBMCs) from cynomolgus macaques after VSVΔG/EBOVgp immunization and subsequent EBOV challenge. We found a controlled transcriptional response that transitioned to immune regulation as the EBOV was cleared. This observatio ...[more]