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Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review.


ABSTRACT: To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars.Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion.The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

SUBMITTER: Pacis MM 

PROVIDER: S-EPMC4363227 | biostudies-other | 2015 Mar

REPOSITORIES: biostudies-other

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Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review.

Pacis Michelle M MM   Fortin Chelsea N CN   Zarek Shvetha M SM   Mumford Sunni L SL   Segars James H JH  

Journal of assisted reproduction and genetics 20141230 3


<h4>Purpose</h4>To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.<h4>Methods</h4>A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical m  ...[more]

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