Ontology highlight
ABSTRACT:
SUBMITTER: Tsai FL
PROVIDER: S-EPMC4438241 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Molecular and cellular biology 20150413 12
The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate into this phosphorylation cascade is incompletely understood. Here, through analysis of a unique mcm allele targeting a specific ATPase active site (mcm2DENQ), we show that the Mcm2-7 replicative helicase has a novel DRC function as part of the signal transduction cascade. This allele exhibits normal downstream mediator (Mrc1) phosphorylat ...[more]