Ontology highlight
ABSTRACT:
SUBMITTER: Krol J
PROVIDER: S-EPMC4468907 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Nature communications 20150604
Brain regions, such as the cortex and retina, are composed of layers of uniform thickness. The molecular mechanism that controls this uniformity is not well understood. Here we show that during mouse postnatal development the timed expression of Rncr4, a retina-specific long noncoding RNA, regulates the similarly timed processing of pri-miR-183/96/182, which is repressed at an earlier developmental stage by RNA helicase Ddx3x. Shifting the timing of mature miR-183/96/182 accumulation or interfer ...[more]