Ontology highlight
ABSTRACT:
SUBMITTER: Eckner R
PROVIDER: S-EPMC453080 | biostudies-other | 1991 Nov
REPOSITORIES: biostudies-other
The EMBO journal 19911101 11
We have analysed nucleocytoplasmic export of mRNAs in primate cells with the aim of identifying signals promoting RNA transport. Our results demonstrate that sequences directing either histone mRNA 3' processing or cleavage/polyadenylation of mRNA stimulate nucleocytoplasmic RNA transport. To elucidate the nature of this stimulation, we engineered test gene transcripts which could obtain a mature histone 3' end by the RNA cleaving activity of a cis-acting ribozyme, thus circumventing the cellula ...[more]