Toward a rational design of combination therapy in cancer.

ABSTRACT: By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie monocyte pro-angiogenic activity have a strong predictive value for breast cancer patient relapse - free survival.

SUBMITTER: Doucey MA 

PROVIDER: S-EPMC4589060 | biostudies-other | 2015 Nov

REPOSITORIES: biostudies-other