Ontology highlight
ABSTRACT:
SUBMITTER: Lim C
PROVIDER: S-EPMC4607668 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Cell reports 20151001 2
Extrinsic cues from the niche are known to regulate adult stem cell self-renewal versus differentiation. Here, we report that an aminopeptidase Slamdance (Sda) acts in the Drosophila testicular niche to maintain germline stem cells (GSCs) and regulate progenitor germ cell dedifferentiation. Mutations in sda lead to dramatic testicular niche deterioration and stem cell loss. Recombinant Sda has specific aminopeptidase activity in vitro, and the in vivo function of Sda requires an intact aminopept ...[more]