ISG15: A double edged sword in cancer.

ABSTRACT: Interferon-Stimulated Gene 15 (ISG15) transcript is aberrantly expressed in most human malignancies, suggesting that it has a protumor function. However, at the protein level ISG15 has both protumor and immunomodulatory antitumor functions. Therapeutic strategies to maximize the latter may benefit cancer patients overexpressing the ISG15 pathway.

SUBMITTER: Desai SD 

PROVIDER: S-EPMC4635879 | biostudies-other | 2015 Dec

REPOSITORIES: biostudies-other