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FTO: linking m6A demethylation to adipogenesis.

ABSTRACT: Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

SUBMITTER: Ben-Haim MS 

PROVIDER: S-EPMC4650590 | biostudies-other | 2015 Jan

REPOSITORIES: biostudies-other

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