Ontology highlight
ABSTRACT:
SUBMITTER: Rosati A
PROVIDER: S-EPMC4659838 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Nature communications 20151102
The incidence and death rate of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years, therefore the identification of novel targets for treatment is extremely important. Interactions between cancer and stromal cells are critically involved in tumour formation and development of metastasis. Here we report that PDAC cells secrete BAG3, which binds and activates macrophages, inducing their activation and the secretion of PDAC supporting factors. We also identify IFITM-2 as a BAG3 ...[more]