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Characterizing allelic association in the genome era.

ABSTRACT: Whole genome data are allowing the estimation of population genetic parameters with an accuracy not imagined 50 years ago. Variation in these parameters along the genome is being found empirically where once only approximate theoretical values were available. Along with increased information, however, has come the issue of multiple testing and the realization that high values of the coefficients of variation of quantities such as relatedness measures may make it difficult to draw inferences. This review concentrates on measures of allelic association within and between individuals and within and between populations.

SUBMITTER: Weir BS 

PROVIDER: S-EPMC4688043 | biostudies-other | 2010 Dec

REPOSITORIES: biostudies-other

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Characterizing allelic association in the genome era.

Weir B S BS   Laurie C C CC  

Genetics research 20101201 5-6

Whole genome data are allowing the estimation of population genetic parameters with an accuracy not imagined 50 years ago. Variation in these parameters along the genome is being found empirically where once only approximate theoretical values were available. Along with increased information, however, has come the issue of multiple testing and the realization that high values of the coefficients of variation of quantities such as relatedness measures may make it difficult to draw inferences. Thi  ...[more]

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