Ontology highlight
ABSTRACT:
SUBMITTER: Layer RM
PROVIDER: S-EPMC4697868 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Nature methods 20151109 1
Genotype Query Tools (GQT) is an indexing strategy that expedites analyses of genome-variation data sets in Variant Call Format based on sample genotypes, phenotypes and relationships. GQT's compressed genotype index minimizes decompression for analysis, and its performance relative to that of existing methods improves with cohort size. We show substantial (up to 443-fold) gains in performance over existing methods and demonstrate GQT's utility for exploring massive data sets involving thousands ...[more]