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Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea-induced t-MDS/AML.


ABSTRACT: Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine-mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observed phenomenon.

SUBMITTER: Horton JD 

PROVIDER: S-EPMC4706408 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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