Ontology highlight
ABSTRACT:
SUBMITTER: Zhou A
PROVIDER: S-EPMC4718723 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Zhou Anna A Rohou Alexis A Schep Daniel G DG Bason John V JV Montgomery Martin G MG Walker John E JE Grigorieff Nikolaus N Rubinstein John L JL
eLife 20151006
Adenosine triphosphate (ATP), the chemical energy currency of biology, is synthesized in eukaryotic cells primarily by the mitochondrial ATP synthase. ATP synthases operate by a rotary catalytic mechanism where proton translocation through the membrane-inserted FO region is coupled to ATP synthesis in the catalytic F1 region via rotation of a central rotor subcomplex. We report here single particle electron cryomicroscopy (cryo-EM) analysis of the bovine mitochondrial ATP synthase. Combining cry ...[more]