Ontology highlight
ABSTRACT:
SUBMITTER: Gomes Fernandes M
PROVIDER: S-EPMC4720007 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Stem cell reports 20151217 1
Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive reporter transgene. Activation of the BMP-SMAD reporter transgene in naive mESCs correlated with lower levels of genomic DNA methylation, high expression of 5-methylcytosine hydroxylases Tet1/2 and low levels of DNA methyltransferases Dnmt3a/b. Moreover ...[more]