Ontology highlight
ABSTRACT:
SUBMITTER: Liu JF
PROVIDER: S-EPMC4747375 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Liu Ju-Fang JF Tsao Ya-Ting YT Hou Chun-Han CH
Oncotarget 20151201 38
Osteosarcoma is a common, high malignant, and metastatic bone cancer. Amphiregulin (AREG) has been associated with cancer cellular activities. However, the effect of AREG on metastasis activity in human osteosarcoma cells has yet to be determined. We determined that AREG increases the expression of intercellular adhesion molecule-1 (ICAM-1) through PI3K/Akt signaling pathway via its interaction with the epidermal growth factor receptor, thus resulting in the enhanced cell migration of osteosarco ...[more]