(Compl)Ex-Th17-Treg cell inter-relationship.

ABSTRACT: Codependent development and Th17-to-FoxP3(+) T cell inter-conversion account for the enigmatic coexistence of IL17-producing and FoxP3(+) cells in tumor-associated inflammation. In addition to Treg cells, exTh17-FoxP3(+) cells present a novel subpopulation of FoxP3(+) cells. Yin-yang of IL17(+) and FoxP3(+) cells presents an important principle for improved approaches in cancer immunotherapy.

SUBMITTER: Obermajer N 

PROVIDER: S-EPMC4760333 | biostudies-other | 2016

REPOSITORIES: biostudies-other