Ontology highlight
ABSTRACT:
SUBMITTER: Stanley RJ
PROVIDER: S-EPMC4795700 | biostudies-other | 2016
REPOSITORIES: biostudies-other
PloS one 20160317 3
G proteins are an important family of signalling molecules controlled by guanine nucleotide exchange and GTPase activity in what is commonly called an 'activation/inactivation cycle'. The molecular mechanism by which guanine nucleotide exchange factors (GEFs) catalyse the activation of monomeric G proteins is well-established, however the complete reversibility of this mechanism is often overlooked. Here, we use a theoretical approach to prove that GEFs are unable to positively control G protein ...[more]