Lactic acid polarizes macrophages to a tumor-promoting state.

ABSTRACT: Tumor-associated macrophages have been associated with a poor prognosis in most types of tumors. However, tumor-derived signals that activate macrophages have not been well defined. We review our recent finding that tumor-derived lactic acid is necessary and sufficient to polarize tumor-associated macrophages to a tumor-promoting state.

SUBMITTER: Colegio OR 

PROVIDER: S-EPMC4839384 | biostudies-other | 2016 Mar

REPOSITORIES: biostudies-other