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Towards "bionic" proteins: replacement of continuous sequences from HIF-1? with proteomimetics to create functional p300 binding HIF-1? mimics.

ABSTRACT: Using the HIF-1? transcription factor as a model, this manuscript illustrates how an extended sequence of ?-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an ?-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1? from which it is derived.

SUBMITTER: Burslem GM 

PROVIDER: S-EPMC4843846 | biostudies-other | 2016 Apr

REPOSITORIES: biostudies-other

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Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.

Burslem George M GM   Kyle Hannah F HF   Breeze Alexander L AL   Edwards Thomas A TA   Nelson Adam A   Warriner Stuart L SL   Wilson Andrew J AJ  

Chemical communications (Cambridge, England) 20160401 31

Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived. ...[more]