Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer.

ABSTRACT: Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.

SUBMITTER: Cook KL 

PROVIDER: S-EPMC4845173 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other