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Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors.


ABSTRACT: The BCL-2/BCL-XL inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have improved therapeutic profiles for the treatment of cancer.

SUBMITTER: Leverson JD 

PROVIDER: S-EPMC4845185 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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