Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors.
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ABSTRACT: The BCL-2/BCL-XL inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have improved therapeutic profiles for the treatment of cancer.
SUBMITTER: Leverson JD
PROVIDER: S-EPMC4845185 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
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