The stress of coping with E2F loss.

ABSTRACT: E2F transcription factors are key regulators of cellular proliferation, and altered E2F activity is a common feature of tumor cells. Thus, E2F targeting is being explored as a therapeutic strategy in cancer. Importantly, recent mouse knockout studies show that concomitant loss of E2f1/E2f2 activity is associated with increased genomic instability and oncogenic potential in normal differentiating cells, a finding that might have implications for cancer therapy.

SUBMITTER: Iglesias-Ara A 

PROVIDER: S-EPMC4845195 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other