Ontology highlight
ABSTRACT:
SUBMITTER: Baleriola J
PROVIDER: S-EPMC4865816 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Baleriola Jimena J Álvarez-Lindo Noemí N de la Villa Pedro P Bernad Antonio A Blanco Luis L Suárez Teresa T de la Rosa Enrique J EJ
Scientific reports 20160513
Programmed cell death occurs naturally at different stages of neural development, including neurogenesis. The functional role of this early phase of neural cell death, which affects recently differentiated neurons among other cell types, remains undefined. Some mouse models defective in DNA double-strand break (DSB) repair present massive cell death during neural development, occasionally provoking embryonic lethality, while other organs and tissues remain unaffected. This suggests that DSBs occ ...[more]